Research Library

Health Conditions

Evidence-based research summaries for the most common health conditions. Each guide includes cause, research findings, and evidence-graded interventions.

70+
Condition guides
Sleep⭐ Strong
Sleep Disorders: Causes, Research & Evidence-Based Solutions
Comprehensive review of sleep quality, duration, and clinical interventions from CBT-I to supplementation. 12 studies analyzed.
8 min · 12 studiesRead
Mental Health⭐ Strong
Anxiety: Evidence-Based Research Summary
From GAD to stress-induced anxiety — causes, evidence-based interventions, and supplement support. 18 studies reviewed.
10 min · 18 studiesRead
Energy◐ Moderate
Chronic Fatigue: Research Overview & Contributing Factors
Multifactorial causes of persistent fatigue and what peer-reviewed research says about nutritional, hormonal, and lifestyle interventions.
7 min · 9 studiesRead
Cardiovascular⭐ Strong
High Blood Pressure: Lifestyle & Research Evidence
Evidence summary on hypertension management through diet, exercise, and targeted supplementation. DASH diet and beyond.
9 min · 22 studiesRead
Mental Health⭐ Strong
Depression: Research Summary & Biological Mechanisms
Biological underpinnings of depression, clinical treatment evidence, and the emerging role of nutrition and lifestyle in symptom management.
11 min · 25 studiesRead
Metabolic⭐ Strong
Type 2 Diabetes: Risk Factors & Lifestyle Research
Research on insulin resistance, glycemic control, and evidence-based lifestyle and dietary interventions for type 2 diabetes management.
10 min · 30+ studiesRead
Pain◐ Moderate
Chronic Back Pain: Evidence-Based Interventions
What research says about exercise, manual therapy, and nutritional approaches for chronic lower back pain management.
8 min · 14 studiesRead
Digestive◐ Moderate
Irritable Bowel Syndrome: Diet & Research Evidence
Evidence on low-FODMAP diet, probiotics, and lifestyle interventions for IBS symptom management.
9 min · 16 studiesRead
Cardiovascular⭐ Strong
Cholesterol: LDL, HDL, Statins & Dietary Research
Each 1 mmol/L LDL reduction cuts cardiovascular events by 22%. Evidence on statins, diet, and lifestyle interventions for optimal lipid profiles.
10 min · 20+ studiesRead
Metabolic⭐ Strong
Obesity & Weight Management: Research Evidence
Biology of obesity, dietary approaches, exercise for weight maintenance, and GLP-1 medications (semaglutide, tirzepatide) producing 15–22% weight loss.
11 min · 25+ studiesRead
Hormonal⭐ Strong
Thyroid Health: Hypothyroidism & Hashimoto's Research
Affects 5% of adults. Evidence on TSH testing, levothyroxine treatment, selenium, vitamin D, and dietary factors for Hashimoto's autoimmune thyroiditis.
10 min · 18 studiesRead
Hormonal◐ Moderate
PCOS: Polycystic Ovary Syndrome Research & Management
Affects 8–13% of women. Evidence on insulin resistance, inositol supplementation, low-GI diet, exercise, and medication options for PCOS management.
11 min · 20 studiesRead
Mental Health⭐ Strong
ADHD: Research, Mechanisms & Evidence-Based Treatment
Affects 5–7% of children and 4% of adults. Stimulant medications achieve 70–80% response rates. Exercise is among the best non-pharmacological interventions. 22 studies reviewed.
11 min · 22 studiesRead
Mental Health⭐ Strong
PTSD: Neurobiology & Evidence-Based Treatment Research
EMDR, Prolonged Exposure, and CPT achieve 60–80% response rates. MDMA-assisted therapy shows 67–71% remission in Phase 3 trials. 20 studies reviewed.
11 min · 20 studiesRead
Cognitive◐ Moderate
Brain Fog: Causes, Research & Evidence-Based Solutions
Reversible causes including B12, iron, thyroid, sleep, and neuroinflammation. Long COVID brain fog affects 10–30% of survivors. 16 studies reviewed.
9 min · 16 studiesRead
Mental Health◐ Moderate
Burnout: Biological Mechanisms & Evidence-Based Recovery
WHO-classified occupational phenomenon with measurable biological correlates — HPA dysregulation, hippocampal atrophy, immune suppression. 17 studies reviewed.
9 min · 17 studiesRead
Digestive⭐ Strong
Acid Reflux & GERD: Research & Evidence-Based Management
Affects ~20% of adults. PPIs heal esophagitis in 70–80% at 8 weeks. Weight loss and head-of-bed elevation have the strongest lifestyle evidence. 18 studies reviewed.
9 min · 18 studiesRead
Digestive⭐ Strong
Constipation: Causes, Fiber & Evidence-Based Relief
Affects 14–16% of adults. Psyllium husk, kiwifruit, and prunes have RCT evidence. Probiotics increase stool frequency by 1.3x per week. 15 studies reviewed.
8 min · 15 studiesRead
Digestive⭐ Strong
Crohn's Disease & IBD: Research & Evidence-Based Management
Biologic therapies achieve mucosal healing in 40–60% of patients. Smoking cessation is the most impactful lifestyle change in Crohn's. Vitamin D near-universally deficient. 20 studies reviewed.
11 min · 20 studiesRead
Neurological⭐ Strong
Migraines & Headaches: Research & Treatment Evidence
Affects 1 billion globally. CGRP antibodies cut migraine days by 50%+. Magnesium, riboflavin, and aerobic exercise all have RCT prevention evidence. 20 studies reviewed.
10 min · 20 studiesRead
Pain⭐ Strong
Arthritis: Osteoarthritis & Rheumatoid Arthritis Research
Exercise reduces OA pain comparably to NSAIDs (Cochrane 54 RCTs). Biologic DMARDs prevent joint destruction in RA. Omega-3 and curcumin have strong supplement evidence. 22 studies reviewed.
11 min · 22 studiesRead
Pain◐ Moderate
Fibromyalgia: Mechanisms & Evidence-Based Management
Central sensitization disorder affecting 2–4% of adults. Aerobic exercise has the single strongest evidence base. FDA-approved: duloxetine, milnacipran, pregabalin. 18 studies reviewed.
10 min · 18 studiesRead
Hormonal⭐ Strong
Menopause: Symptoms, HRT & Evidence-Based Management
HRT reduces hot flashes by 75–90% and is most beneficial within 10 years of menopause. Modern re-analysis has substantially rehabilitated HRT safety. 20 studies reviewed.
11 min · 20 studiesRead
Hormonal⭐ Strong
Testosterone & Male Hormonal Health: Research Evidence
TRAVERSE trial (2023) resolved cardiovascular safety concerns. Sleep is the single highest-impact modifiable testosterone factor. Natural approaches reviewed. 20 studies.
10 min · 20 studiesRead
Hormonal◐ Moderate
Cortisol & Adrenal Fatigue: Research & Real Answers
Adrenal fatigue lacks clinical evidence — but HPA axis dysregulation from chronic stress is measurable and real. Ashwagandha, MBSR, and sleep have the strongest evidence. 16 studies.
9 min · 16 studiesRead
Skin⭐ Strong
Acne & Skin Health: Research & Evidence-Based Treatment
Affects 85% of adolescents. Low-GI diet and zinc have RCT evidence. Topical retinoids are first-line. Isotretinoin achieves 60–70% permanent remission. 20 studies reviewed.
10 min · 20 studiesRead
Skin⭐ Strong
Hair Loss (Alopecia): Causes & Evidence-Based Treatments
Iron deficiency is the most missed cause. JAK inhibitors FDA-approved for alopecia areata (2022). Target ferritin above 70 ng/mL for hair health. 18 studies reviewed.
10 min · 18 studiesRead
Immune◐ Moderate
Autoimmune Disease: Mechanisms & Evidence-Based Management
VITAL trial: Vitamin D3 + omega-3 reduces autoimmune disease incidence by 39%. Gut dysbiosis and intestinal permeability are central mechanisms. 18 studies reviewed.
10 min · 18 studiesRead
Organ Health⭐ Strong
Kidney Health: CKD, Prevention & Evidence-Based Research
Affects 15% of adults; 90% unaware. SGLT2 inhibitors reduce CKD progression by 30–40%. NSAIDs are the most harmful common OTC drug for kidneys. 18 studies reviewed.
10 min · 18 studiesRead